Magnetically navigated nano-PROTAC ameliorates acute lung harm | Journal of Nanobiotechnology


  • Gorman EA, O’Kane CM, McAuley DF. Acute respiratory misery syndrome in adults: analysis, outcomes, long-term sequelae, and administration. Lancet. 2022;400(10358):1157–70.

    Article 
    PubMed 

    Google Scholar
     

  • Fan E, Brodie D, Slutsky AS. Acute respiratory misery syndrome: advances in analysis and remedy. JAMA. 2018;319(7):698–710.

    Article 
    PubMed 

    Google Scholar
     

  • Ma W, Tang S, Yao P, Zhou T, Niu Q, Liu P, et al. Advances in acute respiratory misery syndrome: specializing in heterogeneity, pathophysiology, and therapeutic methods. Sign Transduct Goal Ther. 2025;10(1): 75.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Bos LDJ, Ware LB. Acute respiratory misery syndrome: causes, pathophysiology, and phenotypes. Lancet. 2022;400(10358):1145–56.

    Article 
    PubMed 

    Google Scholar
     

  • Solar ZC, Liao R, Xian C, Lin R, Wang L, Fang Y, et al. Pure pachypodol built-in, lung focused and inhaled lipid nanomedicine ameliorates acute lung harm by way of anti-inflammation and repairing lung barrier. J Management Launch. 2024;375:300–15.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Xu Y, Lv L, Wang Q, Yao Q, Kou L, Zhang H. Rising utility of nanomedicine-based remedy in acute respiratory misery syndrome. Colloids Surf B Biointerfaces. 2024;237: 113869.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Matthay MA, Zemans RL, Zimmerman GA, Arabi YM, Beitler JR, Mercat A, et al. Acute respiratory misery syndrome. Nat Rev Dis Primers. 2019;5(1):18.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Chen T, Zhu G, Meng X, Zhang X. Current developments of small molecules with anti-inflammatory actions for the remedy of acute lung harm. Eur J Med Chem. 2020;207: 112660.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Roquilly A, Jacqueline C, Davieau M, Mollé A, Sadek A, Fourgeux C, et al. Alveolar macrophages are epigenetically altered after irritation, resulting in long-term lung immunoparalysis. Nat Immunol. 2020;21(6):636–48.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Chen X, Tang J, Shuai W, Meng J, Feng J, Han Z. Macrophage polarization and its position within the pathogenesis of acute lung harm/acute respiratory misery syndrome. Inflamm Res. 2020;69(9):883–95.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Liang L, Peng W, Qin A, Zhang J, Chen R, Zhou D, et al. Intracellularly synthesized synthetic exosome treats acute lung harm. ACS Nano. 2024;18(32):21009–23.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Park MD, Silvin A, Ginhoux F, Merad M. Macrophages in well being and illness. Cell. 2022;185(23):4259–79.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Liang L, Xu W, Shen A, Fu X, Cen H, Wang S et al. Inhibition of YAP1 exercise ameliorates acute lung harm by promotion of M2 macrophage polarization. MedComm (2020). 2023, 4(3):e293.

  • Li X, Chen G, Zhou X, Peng X, Li M, Chen D, et al. Roles of Akirin1 in early prediction and remedy of graft kidney ischemia–reperfusion harm. Good Drugs. 2024;3(2): e20230043.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Li J, Jiang X, Li H, Gelinsky M, Gu Z. Tailoring supplies for modulation of macrophage destiny. Adv Mater. 2021;33(12): e2004172.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Chen S, Saeed A, Liu Q, Jiang Q, Xu H, Xiao GG, et al. Macrophages in immunoregulation and therapeutics. Sign Transduct Goal Ther. 2023;8(1): 207.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Liu C, Xi L, Liu Y, Mak JCW, Mao S, Wang Z, et al. An inhalable hybrid biomimetic nanoplatform for sequential drug launch and reworking lung immune homeostasis in acute lung harm remedy. ACS Nano. 2023;17(12):11626–44.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Zhu Q, Yu T, Gan S, Wang Y, Pei Y, Zhao Q, et al. TRIM24 facilitates antiviral immunity by mediating K63-linked TRAF3 ubiquitination. J Exp Med. 2020;217(7): e20192083.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Yu T, Gan S, Zhu Q, Dai D, Li N, Wang H, et al. Modulation of M2 macrophage polarization by the crosstalk between Stat6 and Trim24. Nat Commun. 2019;10(1):4353.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Guan X, Xu X, Tao Y, Deng X, He L, Lin Z, et al. Twin focusing on and bioresponsive nano-PROTAC induced exact and efficient lung most cancers remedy. J Nanobiotechnol. 2024;22(1):692.

    Article 
    CAS 

    Google Scholar
     

  • Huang JH, Huang CJ, Yu LN, Guan XL, Liang SW, Li JH, et al. Bioinspired PROTAC-induced macrophage destiny dedication alleviates atherosclerosis. Acta Pharmacol Sin. 2023;44(10):1962–76.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kalluri R, LeBleu VS. The biology, operate, and biomedical purposes of exosomes. Science. 2020, 367(6478):eaau6977. https://doi.org/10.1126/science.aau6977

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhu L, Tian W, Yuan L, Chi C, Wang Y, Xiao Q, et al. Aptamer-based extracellular vesicle isolation, evaluation and therapeutics. Interdiscip Med. 2023;1(2): e20220019.

    Article 

    Google Scholar
     

  • Qiao R, Wang H, Li D, Yang Y, Shu J, Track X, et al. Stevioside protects towards acute kidney harm by inhibiting gasdermin D pathway. Good Drugs. 2024;3(2): e20240010.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Yu D, Li Y, Wang M, Gu J, Xu W, Cai H, et al. Exosomes as a brand new frontier of most cancers liquid biopsy. Mol Most cancers. 2022;21(1):56.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Liang Y, Duan L, Lu J, Xia J. Engineering exosomes for focused drug supply. Theranostics. 2021;11(7):3183–95.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wang J, Yuan S, Tu Y, Lv Z, Cheng H, Ding X. Extracellular vesicles in pores and skin well being, illnesses, and ageing. Interdiscip Med. 2024;2: e20240011.

    Article 

    Google Scholar
     

  • Chavda VP, Pandya A, Kumar L, Raval N, Vora LK, Pulakkat S, et al. Exosome nanovesicles: a possible provider for therapeutic supply. Nano Right this moment. 2023;49:101771.

    Article 
    CAS 

    Google Scholar
     

  • Gui X, Zhang H, Zhang R, Li Q, Zhu W, Nie Z, et al. Exosomes included with black phosphorus quantum dots attenuate retinal angiogenesis by way of disrupting glucose metabolism. Mater Right this moment Bio. 2023;19: 100602.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wang P, Wang H, Huang Q, Peng C, Yao L, Chen H, et al. Exosomes from M1-polarized macrophages improve Paclitaxel antitumor exercise by activating macrophages-mediated irritation. Theranostics. 2019;9(6):1714–27.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Gunassekaran GR, Poongkavithai Vadevoo SM, Baek MC, Lee B. M1 macrophage exosomes engineered to foster M1 polarization and goal the IL-4 receptor inhibit tumor progress by reprogramming tumor-associated macrophages into M1-like macrophages. Biomaterials. 2021;278:121137.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Du T, Yang CL, Ge MR, Liu Y, Zhang P, Li H, et al. M1 macrophage derived exosomes irritate experimental autoimmune neuritis by way of modulating Th1 response. Entrance Immunol. 2020;11:1603.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Liu C, Zhang W, Li Y, Chang J, Tian F, Zhao F, et al. Microfluidic sonication to assemble exosome membrane-coated nanoparticles for immune evasion-mediated focusing on. Nano Lett. 2019;19(11):7836–44.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Zhang H, Mao Y, Nie Z, Li Q, Wang M, Cai C, et al. Iron oxide nanoparticles engineered macrophage-derived exosomes for focused pathological angiogenesis remedy. ACS Nano. 2024;18:7644–55.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lin Y, Guan X, Su J, Chen S, Fu X, Xu X, et al. Cell membrane-camouflaged nanoparticles mediated nucleic acids supply. Int J Nanomedicine. 2023;18:8001–21.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Li H, Li S, Lin Y, Chen S, Yang L, Huang X, et al. Synthetic exosomes mediated spatiotemporal-resolved and focused supply of epigenetic inhibitors. J Nanobiotechnol. 2021;19(1):364.

    Article 
    CAS 

    Google Scholar
     

  • Lan Q, Liu C, Yang F, Liu S, Xu J, Solar D. Synthesis of bilayer oleic acid-coated Fe3O4 nanoparticles and their utility in pH-responsive Pickering emulsions. J Colloid Interface Sci. 2007;310(1):260–9.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Zhang D, Teng KX, Zhao L, Niu LY, Yang QZ. Extremely-small nano-assemblies as tumor-targeted and renal clearable theranostic agent for photodynamic remedy. Adv Mater. 2023;35(19): e2209789.

    Article 
    PubMed 

    Google Scholar
     

  • Zoulikha M, Xiao Q, Boafo GF, Sallam MA, Chen Z, He W. Pulmonary supply of SiRNA towards acute lung harm/acute respiratory misery syndrome. Acta Pharm Sin B. 2022;12(2):600–20.

  • Martin TR, Zemans RL, Ware LB, Schmidt EP, Riches DWH, Bastarache L, et al. New insights into scientific and mechanistic heterogeneity of the acute respiratory misery syndrome: abstract of the Aspen Lung Convention 2021. Am J Respir Cell Mol Biol. 2022;67(3):284–308.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Qiao Q, Liu X, Yang T, Cui Ok, Kong L, Yang C, et al. Nanomedicine for acute respiratory misery syndrome: the most recent utility, focusing on technique, and rational design. Acta Pharm Sin B. 2021;11(10):3060–91.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Liao R, Solar ZC, Wang L, Xian C, Lin R, Zhuo G, et al. Inhalable and bioactive lipid-nanomedicine primarily based on Bergapten for focused acute lung harm remedy by way of orchestrating macrophage polarization. Bioact Mater. 2025;43:406–22.

    CAS 
    PubMed 

    Google Scholar
     

  • Békés M, Langley DR, Crews CM. Protac focused protein degraders: the previous is prologue. Nat Rev Drug Discov. 2022;21(3):181–200.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Huang J, Yao Z, Li B, Ping Y. Focused supply of PROTAC-based prodrug activated by bond-cleavage bioorthogonal chemistry for microneedle-assisted most cancers remedy. J Management Launch. 2023;361:270–9.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Yang L, Yang Y, Zhang J, Li M, Yang L, Wang X, et al. Sequential responsive nano-PROTACs for exact intracellular supply and enhanced degradation efficacy in colorectal most cancers remedy. Sign Transduct Goal Ther. 2024;9(1): 275.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhang HT, Peng R, Chen S, Shen A, Zhao L, Tang W, et al. Versatile nano-PROTAC-induced epigenetic reader degradation for environment friendly lung most cancers remedy. Adv Sci. 2022;9(29):e2202039.

    Article 

    Google Scholar
     

  • Zhang Y, Liu Q, Zhang X, Huang H, Tang S, Chai Y, et al. Current advances in exosome-mediated nucleic acid supply for most cancers remedy. J Nanobiotechnol. 2022;20(1):279.

    Article 
    CAS 

    Google Scholar
     

  • Duan L, Xu L, Xu X, Qin Z, Zhou X, Xiao Y, et al. Exosome-mediated supply of gene vectors for gene remedy. Nanoscale. 2021;13(3):1387–97.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Zhang L, Lin Y, Li S, Guan X, Jiang X. In situ reprogramming of tumor-associated macrophages with internally and externally engineered exosomes. Angew Chem Int Ed. 2023;62(11): e202217089.

    Article 
    CAS 

    Google Scholar
     

  • Lin Y, Yi M, Guan X, Chen E, Yang L, Li S, et al. Two birds with one stone technique for the lung most cancers remedy with bioinspired AIE aggregates. J Nanobiotechnol. 2023;21(1):49.

  • Tian Y, Han W, Yeung KL. Magnetic microsphere scaffold-based tender microbots for focused mesenchymal stem cell supply. Small. 2023;19(32): e2300430.

    Article 
    PubMed 

    Google Scholar
     

  • Li N, Fei P, Tous C, Rezaei Adariani M, Hautot ML, Ouedraogo I, et al. Human-scale navigation of magnetic microrobots in hepatic arteries. Sci Robotic. 2024;9(87): eadh8702.

    Article 
    PubMed 

    Google Scholar
     

  • Chen J, Ren T, Xie L, Hu H, Li X, Maitusong M, et al. Enhancing aortic valve drug supply with PAR2-targeting magnetic nano-cargoes for calcification alleviation. Nat Commun. 2024;15(1):557.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhang H, Li Z, Gao C, Fan X, Pang Y, Li T, et al. Twin-responsive biohybrid neutrobots for lively goal supply. Sci Robotic. 2021;6(52): eaaz9519.

    Article 
    PubMed 

    Google Scholar
     

  • Mathieu M, Martin-Jaular L, Lavieu G, Théry C. Specificities of secretion and uptake of exosomes and different extracellular vesicles for cell-to-cell communication. Nat Cell Biol. 2019;21(1):9–17.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Nowak-Jary J, Machnicka B. Pharmacokinetics of magnetic iron oxide nanoparticles for medical purposes. J Nanobiotechnol. 2022;20(1):305.

    Article 
    CAS 

    Google Scholar
     

  • Zhao D, Zhu T, Li J, Cui L, Zhang Z, Zhuang X, Ding J. Poly(lactic-co-glycolic acid)-based composite bone-substitute supplies. Bioact Mater. 2021;6(2):346–60.

    CAS 
    PubMed 

    Google Scholar
     

  • Related Articles

    LEAVE A REPLY

    Please enter your comment!
    Please enter your name here

    Latest Articles