The mixing of gold nanoparticles (AuNPs) with lipid bilayers offers rise to highly effective synergistic results arising from nanoscale interactions. Exact management over these interactions allows the rational design of hybrid AuNP–lipid membrane multifunctional composites, unlocking superior analytical instruments and cutting-edge biomedical functions. From a supplies design standpoint, functionalizing AuNPs with lipid membranes reduces cytotoxicity and enhances stability in advanced organic environments. This biomimetic technique additionally allows exact modulation of interactions at organic interfaces, opening new avenues to endow AuNPs with selective recognition and focusing on talents. Importantly, the mixture results in emergent collective behaviors. For example, the self-assembly of AuNPs on lipid membranes creates plasmonic ‘sizzling spots’ that amplify Raman alerts for ultrasensitive SERS-based diagnostics. Membrane-embedded AuNPs also can act as nanoscale heaters, enabling spatiotemporally managed drug launch by means of light-triggered lipid part transitions or nanomechanical disruption of the lipid carriers. Moreover, membrane-mediated AuNP clustering enhances magnetic, catalytic, and optical responses, contributing to the event of good nanomotors and multifunctional therapeutic platforms. These synergistic functionalities come up particularly from the interaction between AuNPs and lipid architectures and can’t be replicated by both system alone. This evaluate critically explores the purposeful synergy between AuNPs and lipid membranes, highlights current key developments, addresses present challenges, and descriptions revolutionary functions in nanomedicine, together with focused drug supply, photothermal remedy, and biomolecular sensing.
