Antibacterial nanoagents have been more and more developed as a result of their favorable biocompatibility, cost-effective uncooked supplies, and different chemical or optical properties. Nonetheless, there may be nonetheless a urgent want for antibacterial nanoagents that exhibit excellent bacteria-binding capabilities and excessive antibacterial effectivity. On this examine, we constructed a multifunctional cascade bioreactor (GCDCO) as a novel antibacterial agent. This concerned incorporating carbon dots (CDs), cobalt sulfide quantum dots (CoSx QDs), and glucose oxidase (GOx) to boost bacterial inhibition below daylight irradiation. The GCDCO demonstrated extremely environment friendly antibacterial capabilities attributed to its favorable photothermal properties, photodynamic exercise, in addition to the synergistic results of hyperthermia, glucose-augmented chemodynamic motion, and extra photodynamic exercise. Inside this cascade bioreactor, CDs performed the position of a photosensitizer for photodynamic remedy (PDT), able to producing ˙O2− even below photo voltaic gentle irradiation. The CoSx QDs not solely functioned as a catalytic part to decompose hydrogen peroxide (H2O2) and generate hydroxyl radicals (˙OH), however in addition they served as warmth mills to boost the Fenton-like catalysis course of. Moreover, GOx was included into this cascade bioreactor to internally provide H2O2 by consuming glucose for a Fenton-like response. Because of this, GCDCO might generate a considerable quantity of reactive oxygen species (ROS), resulting in a major synergistic impact that vastly induced bacterial dying. Moreover, the in vitro antibacterial experiment revealed that GCDCO displayed notably enhanced antibacterial exercise towards E. coli (99+ %) when mixed with glucose below simulated daylight, surpassing the efficacy of the person parts. This underscores its outstanding effectivity in combating bacterial progress. Taken collectively, our GCDCO demonstrates vital potential to be used within the routine remedy of pores and skin infections amongst diabetic sufferers.